CbBio


Hello, I am a Molecular Microbiologist by training. You can find more information in my profesional web [here]. 

I conducted research on Bacterial taxonomy under the supervision of Prof Jose E. Garcia de los Rios (USP, Madrid) and Prof. Michael McClelland (former Sidney Kimmel Cancer Center-SKCC, La Jolla California), I conducted several studies of microbiota in wild birds and also discovered a new bacterial species, Erwinia toletana (Rojas et al, IJSEM, 2004*; In memoriam of Laurent Sutra, one of the co-authors of the manuscript.) 

After a short posdoctoral research at the SKCC (La Jolla, CA), in 2000 I was awarded a NASA-NSCORT fellowship to conduct research in the lab of Prof. Russell F. Doolittle in UCSD. This constituted my transition to Bioinformatics and Computational Biology, although I still did some experimental work to complement my findings. I studied evolutionary conservation of serin proteases in metazoans isolating those from sponges and cnidarians (Rojas & Doolittle, J Mol Evol 2002).

Later on I moved to the Burnham Institute under Prof. Adam Godzik, where I conducted research in structural Bioinformatics in the Systems Biology and Bioinformatics Department. There I focused on computational analyses of protein families involved in apoptosis and immunity, as well as in mechanistic aspects of protein function (Reed JC, et al, Gen Res 2003; Liu et al, Prot. Sci., 2003; Magnusson et al, PNAS 2004; etc). 

 

I returned to Spain in late 2003 to work in the Spanish National Biotechnology Center (CNB-CSIC, Madrid) as a posdoctoral associate where I continued my research in structure/function prediction with emphasis in mechanistic aspects of protein function (Rojas et al, FEBS J, 2005; de Juan et al, Bioinformatics, 2005; Jimenez-Baranda et al, Nat. Cell Biol. 2007; Grego-Bessa et al, Dev. Cell, 2007; etc).

Later on I was appointed as a Staff scientist in the Spanish National Cancer Center (CNIO, Madrid), under Prof. Alfonso Valencia's supervision. There I conducted research in protein evolution, hypothesis generation, and signaling pathways (Sonnenberg et al, J Mol Biol, 2007; Cases et al, Nuc Acids Res, 2007; Sanchez-Pulido et al, TiBS 2007; Proell et al, PlosONE, 2008; etc).

In 2009 I was appointed as head of the Computational Biology and Bioinformatics Group at the Institute of Personalized Medicine of Cancer (IMPPC) in Badalona and a bit later, in June 2012 I got a joint appointment in the Barcelona Supercomputing Center (BSC). During this time I focused on the evolutionary study of signal transduction pathways, in particular the RAS superfamily (Rojas et al, J Cell Biol, 2012; etc), sequence/structure features and their impact on biological processes (Manes, et al, FASEB J, 2010, etc), in addition to setting up the High Performance Scientific Computation Facilities at IMPPC. My group also participated in several colaborations (Athiyarath et al, J. Brit. Haematol., 2013; Pons et al, Proteins, 2013, etc.)

Later, in 2013 I moved to the Institute of Biomedicine in Sevilla (IBIS) where I am the principal investigator of the Computational Biology and Bioinformatics Group (CbBIO). We have continued our investigations in signaling pathways, with focus on the DNA Damage Response (Arcas et al., Mol Biol Evol, 2014; Lopez-Contreras et al, Cell Reports, 2013).

In December of 2103 I have been appointed Coordinator of the Computational Molecular Biology Group within the Spanish Society of Biochemistry and Molecular Biology [SEBBM]

More info @ Ana's professional page [HERE].

 

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